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Structure of 3189-48-8
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Indolizine-2-carboxylic acid features a rigid, electron-deficient heterocyclic core that integrates seamlessly into conjugated systems. This carboxylic acid moiety enables direct functionalization or salt formation, enhancing solubility and reactivity in synthetic transformations. The scaffold serves as a privileged building block for bioactive molecule design and materials chemistry applications.
Indolizine-2-carboxylic acid serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its carboxylic acid functionality enables direct derivatization via amide, ester, or acyl chloride formation, while the fused indolizine core provides structural rigidity and enhanced metabolic stability. The compound exhibits good bench stability and facilitates efficient functionalization under standard coupling conditions, making it well-suited for medicinal chemistry campaigns targeting CNS-active compounds and kinase inhibitors.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: