6-Bromo-4-hydroxyquinazoline

Name: 6-Bromo-4-hydroxyquinazoline
Brand: ChemScene
Availability: InStock
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CAS No. 32084-59-6
Cat. No. CS-D1073
Purity≥97%
MDL No.MFCD01219541

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Description

6-Bromo-4-hydroxyquinazoline features a bromine atom at the 6-position and a hydroxyl group at the 4-position, enabling direct functionalization in C–H activation and cross-coupling reactions. This electron-deficient scaffold integrates readily into kinase inhibitor frameworks and serves as a key intermediate in medicinal chemistry campaigns targeting purine analogs.

Application

6-Bromo-4-hydroxyquinazoline serves as a versatile building block for the synthesis of bioactive quinazoline derivatives. The bromo group enables palladium-catalyzed cross-coupling reactions, while the hydroxyl functionality provides a site for derivatization or protection. This compound exhibits good bench stability and facilitates efficient access to kinase inhibitor scaffolds through standard coupling and cyclization protocols.

General Information

CAS No. 32084-59-6
Cat. No. CS-D1073
Purity ≥97%
MDL No. MFCD01219541
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₅BrN₂O
Molecular Weight 225.04
Synonym(s) 6-Bromoquinazolin-4-ol; 6-bromoquinazolin-4(1H)-one
SMILES O=C1NC=NC2=C1C=C(Br)C=C2

Computational Chemistry Data

TPSA 45.75
LogP 1.6856
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Quinazoline compounds

Key Words

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6-Bromo-4-hydroxyquinazoline

CAS No. 32084-59-6

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