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Structure of 321-21-1
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4-Fluoro-2-methylbenzoic acid features a strategically positioned fluorine atom and methyl group on the aromatic ring, enhancing electron-withdrawing character and metabolic stability. This configuration supports efficient coupling reactions in medicinal chemistry, particularly in scaffold diversification for bioactive molecule synthesis under standard conditions.
4-Fluoro-2-methylbenzoic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-methyl and meta-fluoro substituents provide enhanced metabolic stability and modulate electronic properties, while the carboxylic acid group facilitates direct coupling reactions or derivatization. Bench-stable and readily purified by recrystallization, it functions reliably in standard amide, ester, and acyl transfer protocols.
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GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 1759
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H302-H318
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Precautionary Statements : P264-P270-P280-P330-P501
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Lot numbers can be found on the outside label of a product: