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Structure of 321-28-8
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1-Fluoro-2-methoxybenzene features a strategically positioned fluorine atom and methoxy group on adjacent carbons, creating a unique electronic profile ideal for directing electrophilic substitution. This ortho-substituted aryl fluoride exhibits enhanced stability under standard reaction conditions while enabling selective functionalization in synthetic sequences.
1-Fluoro-2-methoxybenzene serves as a versatile aryl building block in medicinal chemistry and agrochemical synthesis, enabling direct electrophilic substitution and transition-metal-catalyzed coupling reactions. Its ortho-fluoro-methoxy arrangement provides orthogonal reactivity for sequential functionalization, with the fluorine acting as a latent handle for nucleophilic substitution. Bench-stable and readily purified by distillation, it facilitates efficient construction of complex heterocyclic scaffolds and drug candidates.
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GHS Pictogram :
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GHS No : GHS02
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Signal Word : Danger
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UN#: 1993
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Class : 3
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Packing Group : Ⅲ
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Hazard Statements : H226
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Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P370+P378-P501
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Lot numbers can be found on the outside label of a product: