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CS-W001157 4
Total: USD 88.00

4-Phenylbenzaldehyde

  • CAS No. 3218-36-8

  • Cat. No. CS-W004664
  • Molecule weight182.22
  • Purity≥97%
  • MDL No.MFCD00006947

*For research and further manufacturing use only, not for direct human use.

4-Phenylbenzaldehyde|CS-W004664

Structure of 3218-36-8

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General Information

  • CAS No. 3218-36-8
  • Cat. No. CS-W004664
  • Purity ≥97%
  • MDL No. MFCD00006947
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₀O
  • Molecular Weight 182.22
  • Synonym(s) Diphenyl-4-carboxaldehyde; 4-Phenylbenzaldehyde
  • SMILES O=CC1=CC=C(C2=CC=CC=C2)C=C1

Description

4-Phenylbenzaldehyde features a rigid, planar aryl-aldehyde architecture that facilitates efficient π–π stacking in supramolecular assemblies. This electron-deficient aldehyde integrates readily into conjugated frameworks and serves as a key building block for functionalized aromatic systems under standard conditions.

Application

4-Phenylbenzaldehyde serves as a versatile building block in synthetic organic chemistry, enabling efficient construction of biaryl and heterocyclic scaffolds. Its conjugated aldehyde functionality exhibits high reactivity in nucleophilic additions, Wittig reactions, and transition-metal-catalyzed couplings. The molecule's bench-stable nature and compatibility with diverse functional groups facilitate straightforward purification and integration into multi-step syntheses, making it a reliable intermediate for medicinal chemistry and materials science applications.

Synthesis

  • Route1

    References

    • Hajipour, Abdol Reza; Mallakpour, Shadpour E.; Samimi, Heshmat A. Synthetic Communications, 2002 , vol. 32, # 24 p. 3831 - 3838
  • Route2

    References

    • Mai, Wenpeng; Gao, Lianxun Synlett, 2006 , # 16 p. 2553 - 2558
  • Route3
    • null|null
      960-16-7
    • In-stock
      4-Bromobenzaldehyde|CS-W001138
      1122-91-4
    • ~99%
    • In-stock
      4-Phenylbenzaldehyde|CS-W004664
      3218-36-8

    References

    • Wu, Lei; Li, Zhi-Wei; Zhang, Feng; He, Yan-Mei; Fan, Qing-Hua Advanced Synthesis and Catalysis, 2008 , vol. 350, # 6 p. 846 - 862

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   3.1661
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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