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Structure of 324-32-3
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2-Methyl-7-(trifluoromethyl)quinoline features a sterically accessible quinoline core enhanced by electron-withdrawing trifluoromethyl and methyl groups. This combination imparts high stability and favorable electronic properties, enabling efficient integration into catalytic systems, ligand frameworks, and advanced pharmaceutical scaffolds under standard bench conditions.
2-Methyl-7-(trifluoromethyl)quinoline serves as a versatile scaffold in medicinal chemistry, enabling efficient construction of bioactive heterocycles. Its electron-deficient quinoline core, combined with orthogonal functional groups, facilitates diverse transformations including palladium-catalyzed couplings and electrophilic substitutions. The trifluoromethyl group enhances metabolic stability and membrane permeability, while the methyl substituent provides a handle for further derivatization. Bench-stable and readily purified by chromatography, it functions effectively in high-throughput synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: