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CS-W001157 4
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6-Methylpyridin-2(1H)-one

  • CAS No. 3279-76-3

  • Cat. No. CS-W011283
  • Purity≥95%
  • MDL No.MFCD00456278

*For research and further manufacturing use only, not for direct human use.

6-Methylpyridin-2(1H)-one|CS-W011283

Structure of 3279-76-3

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General Information

  • CAS No. 3279-76-3
  • Cat. No. CS-W011283
  • Purity ≥95%
  • MDL No. MFCD00456278
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇NO
  • Molecular Weight 109.13
  • Synonym(s) 6-Methylpyridin-2-ol
  • SMILES O=C1NC(C)=CC=C1

Description

6-Methylpyridin-2(1H)-one features a methyl-substituted pyridinone core with enhanced solubility and stability under standard conditions. This bench-stable heterocycle serves as a key scaffold in medicinal chemistry, integrating readily into bioactive molecules through its electron-rich nitrogen and carbonyl functionalities.

Application

6-Methylpyridin-2(1H)-one serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to pyridone-based scaffolds through standard functionalization protocols. Its inherent stability and favorable solubility profile facilitate straightforward purification and compatibility with common coupling reactions. The molecule functions as a key intermediate in the synthesis of bioactive compounds, particularly those requiring ortho-directed metallation or hydrogen-bonding motifs in target molecules.

Synthesis

  • Route1

    References

    • Shiao, Min-Jen; Ku, Wei-Shen; Hwu, Jih Ru Heterocycles, 1993 , vol. 36, # 2 p. 323 - 328
  • Route2

    References

    • Chemische Berichte, , vol. 73, p. 156
  • Route3
    • null|null
      109-06-8
    • ~%
    • In-stock
      6-Methylpyridin-2(1H)-one|CS-W011283
      3279-76-3

    References

    • DE406208 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 14, p. 516

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   32.86
  • LogP   0.68332
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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