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CS-W001157 4
Total: USD 88.00

3-Hydroxy-5-(trifluoromethyl)benzoic acid

  • CAS No. 328-69-8

  • Cat. No. CS-W015347
  • Purity≥98%
  • MDL No.MFCD07368783
  • HazMat Fee +

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    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-Hydroxy-5-(trifluoromethyl)benzoic acid|CS-W015347

Structure of 328-69-8

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Description

3-Hydroxy-5-(trifluoromethyl)benzoic acid features a strategically positioned hydroxyl group and a strongly electron-withdrawing trifluoromethyl substituent, enhancing its utility in medicinal chemistry. The carboxylic acid functionality enables direct coupling reactions, while the ortho-hydroxyl facilitates chelation or intramolecular interactions. This combination delivers enhanced solubility and metabolic stability in bioactive scaffolds.

Application

3-Hydroxy-5-(trifluoromethyl)benzoic acid serves as a versatile building block for medicinal chemistry and agrochemical synthesis, enabling direct incorporation of both phenolic and carboxylic acid functionalities. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the ortho-hydroxyl facilitates downstream derivatization via esterification, ether formation, or metal-catalyzed coupling reactions. The compound exhibits good bench stability and is readily purified by recrystallization, supporting its use in scalable synthetic routes.

General Information

  • CAS No. 328-69-8
  • Cat. No. CS-W015347
  • Purity ≥98%
  • MDL No. MFCD07368783
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅F₃O₃
  • Molecular Weight 206.12
  • Synonym(s) Benzoic acid, 3-hydroxy-5-(trifluoromethyl)-
  • SMILES O=C(O)C1=CC(C(F)(F)F)=CC(O)=C1

Computational Chemistry Data

  • TPSA   57.53
  • LogP   2.1092
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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