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CS-W001157 4
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2-(Trifluorormethoxy)phenol

  • CAS No. 32858-93-8

  • Cat. No. CS-W017348
  • Purity≥98%
  • MDL No.MFCD00236324

*For research and further manufacturing use only, not for direct human use.

2-(Trifluorormethoxy)phenol|CS-W017348

Structure of 32858-93-8

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General Information

  • CAS No. 32858-93-8
  • Cat. No. CS-W017348
  • Purity ≥98%
  • MDL No. MFCD00236324
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅F₃O₂
  • Molecular Weight 178.11
  • Synonym(s) 2-Trifluoromethoxyphenol
  • SMILES C1=C(C(=CC=C1)O)OC(F)(F)F

Description

2-(Trifluoromethoxy)phenol features a trifluoromethoxy group flanking a phenolic hydroxyl, delivering enhanced electron-withdrawal and metabolic stability. This combination imparts high lipophilicity and resistance to oxidative degradation, making it valuable for medicinal chemistry applications requiring robust aromatic scaffolds in bioactive molecule design.

Application

2-(Trifluoromethoxy)phenol serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct functionalization at the phenolic hydroxyl group. Its trifluoromethoxy substituent imparts enhanced metabolic stability and lipophilicity, while the ortho-orientation facilitates intramolecular interactions in target-directed design. The compound exhibits good bench stability and compatibility with standard coupling reactions, facilitating efficient access to fluorinated heterocycles and bioactive scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H317-H319-H412
Precautionary Statements : P261-P264-P270-P272-P273-P280-P302+P352-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.46
  • LogP   2.2908
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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