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Structure of 33097-39-1
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3,6-Difluoropyridazine is a bench-stable, electron-deficient heterocycle featuring two fluorine substituents at the 3- and 6-positions. This configuration enhances reactivity in cross-coupling processes and enables selective functionalization in medicinal chemistry applications.
3,6-Difluoropyridazine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at both C3 and C6 positions via palladium-catalyzed cross-coupling reactions. Its high reactivity and bench stability facilitate efficient construction of complex heterocyclic scaffolds, particularly in the synthesis of kinase inhibitors and CNS-targeted pharmaceuticals. The difluoro substitution pattern enhances metabolic stability and modulates electronic properties, supporting favorable pharmacokinetic profiles in lead optimization campaigns.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: