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Structure of 33167-21-4
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Ethyl 3-(3-chlorophenyl)-3-oxopropanoate features a conjugated enone system flanked by a chlorinated aromatic ring and an ester group, enabling direct participation in Knoevenagel condensations and Michael additions. This bench-stable reagent integrates readily into synthetic sequences requiring electrophilic carbon centers adjacent to electron-withdrawing functionalities.
Ethyl 3-(3-chlorophenyl)-3-oxopropanoate serves as a versatile β-keto ester building block in synthetic organic chemistry, enabling efficient construction of substituted heterocycles and functionalized carbonyl compounds. Its electrophilic enolizable α-position facilitates aldol-type condensations and Michael additions, while the ortho-chlorophenyl group provides a handle for further functionalization via palladium-catalyzed cross-coupling. The compound exhibits good bench stability and is readily purified by distillation or chromatography, making it well-suited for iterative synthesis workflows in medicinal chemistry and process development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: