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Structure of 33282-22-3
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5-(4-Chlorophenyl)isoxazole-3-carboxylic acid features a rigid isoxazole core linked to a para-chlorophenyl group, delivering enhanced electron-withdrawing character and metabolic stability. This structural motif enables direct incorporation into bioactive scaffolds, particularly in medicinal chemistry campaigns targeting kinase inhibition and CNS-penetrant therapeutics. The carboxylic acid functionality provides a handle for derivatization via amide or ester formation under standard coupling conditions.
5-(4-Chlorophenyl)isoxazole-3-carboxylic acid serves as a versatile building block for heterocyclic synthesis, enabling efficient access to bioactive scaffolds via standard coupling and functionalization reactions. Its robust bench stability, combined with orthogonal reactivity of the carboxylic acid and isoxazole ring, facilitates straightforward derivatization and purification. The molecule functions effectively in amide bond formation, Suzuki coupling, and electrophilic substitution, making it valuable for medicinal chemistry and process development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302
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Precautionary Statements : P264-P270-P330-P501
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Lot numbers can be found on the outside label of a product: