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Structure of 333-47-1
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(4-Bromophenyl)(trifluoromethyl)sulfane features a brominated phenyl ring coupled to a trifluoromethylthio group, delivering enhanced stability and electron-withdrawing character. This combination enables efficient coupling in cross-coupling reactions, particularly under palladium catalysis. The molecule’s bench-stable nature and compatibility with standard reaction conditions streamline synthesis workflows in medicinal chemistry and materials science.
(4-Bromophenyl)(trifluoromethyl)sulfane serves as a versatile building block for cross-coupling reactions, enabling the efficient installation of aryl-trifluoromethyl sulfane motifs. Its bromo group facilitates palladium-catalyzed coupling with amines, boronic acids, and other nucleophiles, while the trifluoromethylthio moiety offers enhanced metabolic stability and lipophilicity—key attributes in medicinal chemistry. Bench-stable and readily purified by flash chromatography, it functions reliably in multi-step syntheses of functionalized heterocycles and bioactive scaffolds.
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GHS Pictogram :
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GHS No : GHS02
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Signal Word : Danger
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UN#: 1993
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Class : 3
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Packing Group : Ⅲ
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Hazard Statements : H225-H315-H319-H335
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Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501
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Lot numbers can be found on the outside label of a product: