2-Chloro-5-methoxypyrazine

Name: 2-Chloro-5-methoxypyrazine
Brand: ChemScene
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CAS No. 33332-31-9
Cat. No. CS-W021661
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 33332-31-9

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Description

2-Chloro-5-methoxypyrazine features a pyrazine core functionalized with chlorine and methoxy groups, delivering enhanced electron deficiency and tailored reactivity. This bench-stable heterocycle integrates readily into synthetic routes requiring polar, electron-deficient scaffolds, enabling efficient access to complex molecular architectures in medicinal chemistry and materials science applications.

Application

2-Chloro-5-methoxypyrazine serves as a versatile heterocyclic building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions for C–C bond formation. Its chlorine atom facilitates nucleophilic substitution under mild conditions, while the methoxy group provides orthogonal reactivity and enhanced solubility. The compound exhibits excellent bench stability and is compatible with diverse functional groups, making it well-suited for modular synthesis of bioactive scaffolds and pharmaceutical intermediates.

General Information

CAS No. 33332-31-9
Cat. No. CS-W021661
Purity ≥98%
MDL No. None
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₅ClN₂O
Molecular Weight 144.56
Synonym(s) 2-chloro-5-methoxy-pyrazine
SMILES COC1=NC=C(Cl)N=C1

Computational Chemistry Data

TPSA 35.01
LogP 1.1386
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazine compounds

Key Words

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2-Chloro-5-methoxypyrazine

CAS No. 33332-31-9

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