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Thiolan-3-ol

  • CAS No. 3334-05-2

  • Cat. No. CS-0185375
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Thiolan-3-ol|CS-0185375

Structure of 3334-05-2

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General Information

  • CAS No. 3334-05-2
  • Cat. No. CS-0185375
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₈OS
  • Molecular Weight 104.17
  • Synonym(s) Tetrahydro-thiophen-3-OL
  • SMILES OC1CSCC1

Description

Thiolan-3-ol features a reactive thiol group integrated within a five-membered ring, offering enhanced nucleophilicity and stability under standard conditions. This scaffold enables direct incorporation into bioconjugation workflows and functional materials synthesis, where controlled reactivity and moisture tolerance are essential.

Application

Thiolan-3-ol serves as a versatile thiophene-based building block, enabling efficient access to sulfur-containing heterocycles and functionalized intermediates. Its pendant hydroxyl group enhances solubility and provides a handle for selective derivatization, while the thiol functionality facilitates metal-catalyzed coupling reactions and disulfide formation. The compound exhibits good bench stability and is compatible with standard protecting group strategies, making it valuable in medicinal chemistry and process development workflows.

Synthesis

  • Route1

    References

    • Thier, Ricarda; Mueller, Michael; Taylor, John B.; Pemble, Sally E.; Ketterer, Brian; Guengerich, F. Peter Chemical Research in Toxicology, 1995 , vol. 8, # 3 p. 465 - 472
  • Route2

    References

    • Jones, John O.; McElhinney, R. Stanley Journal of Chemical Research, Miniprint, 1984 , # 5 p. 1501 - 1517
  • Route3
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      1120-59-8
    • ~%
    • In-stock
      Thiolan-3-ol|CS-0185375
      3334-05-2

    References

    • Brown, Herbert C.; Prasad, J. V. N. Vara; Zee, Sheng-Hsu Journal of Organic Chemistry, 1985 , vol. 50, # 10 p. 1582 - 1589

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   0.4842
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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