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Structure of 33626-98-1
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Methyl 6-bromo-2-naphthoate undergoes aromatic Finkelstein reaction followed by hydrolysis to afford 6-iodo-2-naphthoic acid.Methyl 6-bromo-2-naphthoate may be used to synthesize:6-vinyl-2-naphthalencarbaldehydemethyl 6-(3-tert-butyl-4-methoxyphenyl)-2-naphthoatemethyl 6-[3-tert-butyl-4-[(tert-butyldiethylsilyl)oxy]-phenyl]-2-naphthoatemethyl 6-[3-(1-adamantyl)-4-[(tert-butyldimethylsilyl)-oxy]phenyl]-2-naphthoatemethyl 6-[3-(1-adamantyl)-4-[[(2,3-dimethyl-1,3-dioxolan-4-yl)methylloxy]phenyl]-2-naphthoate2-bromo-6-(bromomethyl)naphthalene
Methyl 6-bromo-2-naphthoate serves as a versatile building block in synthetic organic chemistry, enabling bromine-directed functionalization and transition-metal-catalyzed coupling reactions. Its naphthoate scaffold provides enhanced stability and facilitates purification, while the ortho-positioned bromine supports efficient cross-coupling with boronic acids and amines. This reagent functions reliably in palladium-catalyzed transformations, making it well-suited for constructing complex heterocycles and pharmaceutical intermediates under standard bench conditions.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315
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Precautionary Statements : P264-P280-P302+P352-P332+P313-P362+P364
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Lot numbers can be found on the outside label of a product: