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CS-W001157 4
Total: USD 88.00

Thiazole-4-carboxaldehyde

  • CAS No. 3364-80-5

  • Cat. No. CS-W007683
  • Molecule weight113.14
  • Purity≥98%
  • MDL No.MFCD00626896

*For research and further manufacturing use only, not for direct human use.

Thiazole-4-carboxaldehyde|CS-W007683

Structure of 3364-80-5

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General Information

  • CAS No. 3364-80-5
  • Cat. No. CS-W007683
  • Purity ≥98%
  • MDL No. MFCD00626896
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₃NOS
  • Molecular Weight 113.14
  • Synonym(s) Thiazole-4-Carboxyladehyde
  • SMILES C1=C(N=CS1)C=O

Description

Thiazole-4-carboxaldehyde features a reactive aldehyde group positioned at the 4-position of a thiazole ring, enabling direct conjugation in heterocyclic synthesis. This bench-stable, moisture-tolerant scaffold integrates readily into pharmaceutical intermediates and functional materials.

Application

Thiazole-4-carboxaldehyde serves as a versatile building block in medicinal chemistry and synthetic organic chemistry, enabling efficient access to heterocyclic scaffolds via condensation, nucleophilic addition, and transition-metal-catalyzed coupling reactions. Its aldehyde functionality exhibits excellent bench stability and compatibility with diverse functional groups, facilitating straightforward purification and integration into complex molecular architectures. Widely employed in the synthesis of bioactive compounds and pharmaceutical intermediates, it functions as a key moiety for constructing drug-like molecules through well-established transformation pathways.

Synthesis

  • Route1
    • null|null
      936371-70-9
    • ~46%
    • In-stock
      Thiazole-4-carboxaldehyde|CS-W007683
      3364-80-5

    References

    • Zhang, Jianmin; Pettersson, Hanna I.; Huitema, Carly; Niu, Chunying; Yin, Jiang; James, Michael N. G.; Eltis, Lindsay D.; Vederas, John C. Journal of Medicinal Chemistry, 2007 , vol. 50, # 8 p. 1850 - 1864
  • Route2
    • null|null
      3364-76-9
    • ~%
    • In-stock
      Thiazole-4-carboxaldehyde|CS-W007683
      3364-80-5

    References

    • WO2004/60889 A1, ; Page 20 ;
  • Route3
    • null|null
      3364-79-2
    • ~82%
    • In-stock
      Thiazole-4-carboxaldehyde|CS-W007683
      3364-80-5

    References

    • Yuasa, Yoshifumi; Tsuruta, Haruki; Yuasa, Yoko Heterocycles, 2004 , vol. 63, # 10 p. 2385 - 2392

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   0.9556
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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