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CS-W001157 4
Total: USD 88.00

2,3-Dihydroxypropyl benzoate

  • CAS No. 3376-59-8

  • Cat. No. CS-0156546
  • Purity≥97%
  • MDL No.MFCD01084321

*For research and further manufacturing use only, not for direct human use.

2,3-Dihydroxypropyl benzoate|CS-0156546

Structure of 3376-59-8

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General Information

  • CAS No. 3376-59-8
  • Cat. No. CS-0156546
  • Purity ≥97%
  • MDL No. MFCD01084321
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₂O₄
  • Molecular Weight 196.20
  • Synonym(s) None
  • SMILES C1=CC=C(C=C1)C(=O)OCC(CO)O

Description

2,3-Dihydroxypropyl benzoate features a glyceryl-derived backbone with two adjacent hydroxyl groups and a terminal benzoate ester. This structure combines enhanced solubility with stable ester functionality, enabling direct use in polar reaction media. The diol moiety supports hydrogen bonding interactions, while the aromatic ester provides a rigid spacer for conjugation or derivatization.

Application

2,3-Dihydroxypropyl benzoate serves as a versatile diol-protected benzoate building block, enabling selective esterification and orthogonal functional group manipulation in complex molecule synthesis. Its bench-stable nature and compatibility with standard purification methods facilitate efficient handling in medicinal chemistry and natural product workflows. Functions as a key intermediate in the construction of glycoside analogs and bioactive heterocycles.

Synthesis

  • Route1
    • null|null
      98760-27-1
    • ~88%
    • In-stock
      2,3-Dihydroxypropyl benzoate|CS-0156546
      3376-59-8

    References

    • Lupin Limited Patent: US2011/257396 A1, 2011 ; Location in patent: Page/Page column 11 ;
  • Route2

    References

    • Cano, Rafael; Perez, Juana M.; Ramon, Diego J. Applied Catalysis A: General, 2014 , vol. 470, p. 177 - 182
  • Route3
    • null|null
      98760-25-9
    • ~78%
    • In-stock
      2,3-Dihydroxypropyl benzoate|CS-0156546
      3376-59-8

    References

    • Kotsuki, Hiyoshizo; Kataoka, Masanori; Nishizawa, Hitoshi Tetrahedron Letters, 1993 , vol. 34, # 25 p. 4031 - 4034

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   66.76
  • LogP   0.1966
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   4

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