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2-((tert-Butoxycarbonyl)amino)-3-(pyridin-4-yl)propanoic acid

  • CAS No. 33814-94-7

  • Cat. No. CS-0154462
  • Molecule weight266.29
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-((tert-Butoxycarbonyl)amino)-3-(pyridin-4-yl)propanoic acid|CS-0154462

Structure of 33814-94-7

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General Information

  • CAS No. 33814-94-7
  • Cat. No. CS-0154462
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₈N₂O₄
  • Molecular Weight 266.29
  • Synonym(s) 4-Pyridinepropionicacid, a-(carboxyamino)-, N-tert-butylester (8CI)
  • SMILES CC(C)(OC(NC(C(O)=O)CC1=CC=NC=C1)=O)C

Description

This pyridyl-substituted amino acid derivative features a tert-butoxycarbonyl-protected amine and a carboxylic acid functionality, enabling direct incorporation into peptide synthesis. The para-pyridyl group enhances solubility and provides a handle for downstream functionalization, while the Boc protection ensures stability during reaction workflows.

Application

2-((tert-Butoxycarbonyl)amino)-3-(pyridin-4-yl)propanoic acid serves as a versatile building block for synthesizing bioactive heterocyclic scaffolds and peptidomimetics. The protected amine and carboxylic acid functionalities enable orthogonal transformations in multistep syntheses, while the pyridin-4-yl group imparts favorable electronic and solubility properties. Bench-stable and readily purified by flash chromatography, it facilitates efficient coupling reactions and downstream deprotection protocols in medicinal chemistry workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   88.52
  • LogP   1.602
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   4

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