Methyl (R)-2-(pyrrolidin-2-yl)acetate hydrochloride

Name: Methyl (R)-2-(pyrrolidin-2-yl)acetate hydrochloride
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CAS No. 340040-67-7
Cat. No. CS-0137047
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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Methyl (R)-2-(pyrrolidin-2-yl)acetate hydrochloride|CS-0137047

Structure of 340040-67-7

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General Information

CAS No. 340040-67-7
Cat. No. CS-0137047
Purity ≥97%
MDL No. None
Storage 4°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₁₄ClNO₂
Molecular Weight 179.64
Synonym(s) 2-Pyrrolidineacetic acid, methyl ester, hydrochloride, (2R)-
SMILES O=C(OC)C[C@@H]1NCCC1.[H]Cl

Description

Methyl (R)-2-(pyrrolidin-2-yl)acetate hydrochloride is a chiral building block featuring a pyrrolidine-containing side chain and a methyl ester functionality. This bench-stable salt delivers enhanced solubility in polar solvents, enabling efficient incorporation into asymmetric synthesis workflows. The stereochemically defined center supports high enantioselectivity in downstream transformations, particularly in medicinal chemistry applications requiring precise control over molecular architecture.

Application

Methyl (R)-2-(pyrrolidin-2-yl)acetate hydrochloride serves as a chiral building block for the synthesis of bioactive molecules, enabling efficient access to pyrrolidine-containing scaffolds. Its bench-stable hydrochloride salt form facilitates handling and purification, while the ester functionality supports versatile downstream transformations. This compound functions effectively in asymmetric synthesis and peptide mimetic development.

Synthesis

Route1
- 132482-05-4
- ~%
- In-stock
  
  340040-67-7
References
- AVENTIS PHARMA DEUTSCHLAND GMBH Patent: US2004/87570 A1, 2004 ;
Route2
- 67-56-1
- 1174705-02-2
- ~%
- In-stock
  
  340040-67-7
References
- Chen, Shaoqing Patent: US2008/234255 A1, 2008 ; Location in patent: Page/Page column 55 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 38.33
LogP 0.7233
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Key Words

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Methyl (R)-2-(pyrrolidin-2-yl)acetate hydrochloride

CAS No. 340040-67-7

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