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Structure of 34328-46-6
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4-Chloro-3-(trifluoromethyl)benzaldehyde features a trifluoromethyl group that enhances electron-withdrawing character and metabolic stability, while the ortho-chloro substituent provides steric and electronic modulation. This combination delivers high reactivity in nucleophilic addition and coupling reactions, enabling efficient access to functionalized aryl scaffolds under standard conditions.
4-Chloro-3-(trifluoromethyl)benzaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of biologically active heterocycles. Its electron-deficient aromatic core facilitates nucleophilic substitution and coupling reactions, while the aldehyde group supports reductive amination, Wittig transformations, and imine formation. The trifluoromethyl and chloro substituents enhance metabolic stability and modulate electronic properties, offering favorable handling and purification characteristics for scalable synthetic workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: