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Structure of 343330-62-1
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3-Bromo-2-methylquinoline is a halogenated quinoline derivative featuring a bromine atom at the 3-position and a methyl group at the 2-position, offering enhanced reactivity in palladium-catalyzed cross-coupling reactions. The electron-deficient aromatic core facilitates efficient C–X bond activation, while the steric profile of the methyl substituent supports selective functionalization. This compound serves as a key intermediate in the synthesis of bioactive heterocycles and advanced materials.
3-Bromo-2-methylquinoline serves as a versatile building block in medicinal chemistry and catalytic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its well-defined halogen functionality. The methyl group at the 2-position enhances regioselectivity in electrophilic substitution and improves metabolic stability in bioactive scaffolds. Bench-stable and readily purified by column chromatography, it functions effectively in Suzuki-Miyaura, Stille, and Negishi coupling protocols for constructing complex heterocyclic architectures.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: