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Structure of 34486-06-1
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6-(Trifluoromethyl)pyridin-2-ol features a trifluoromethyl group at the 6-position and a phenolic hydroxyl at the 2-position, creating a uniquely electron-deficient pyridinic scaffold. This configuration enhances its utility in transition-metal-catalyzed coupling reactions and as a building block for bioactive heterocycles. The compound exhibits robust stability under standard bench conditions and demonstrates favorable solubility in common organic solvents.
6-(Trifluoromethyl)pyridin-2-ol serves as a versatile building block in medicinal chemistry, enabling direct incorporation of a trifluoromethyl group adjacent to a phenolic hydroxyl. Its reactivity facilitates efficient derivatization via etherification, esterification, or metal-catalyzed coupling reactions. The molecule exhibits good bench stability and functional group tolerance, making it well-suited for modular synthesis of bioactive heterocycles and API intermediates.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H319
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Precautionary Statements : P264-P270-P330-P405-P501
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Lot numbers can be found on the outside label of a product: