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Structure of 345-28-8
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Methyl 2-hydroxy-4-(trifluoromethyl)benzoate features a trifluoromethyl group that imparts enhanced electron-withdrawing character and metabolic stability. The phenolic hydroxyl enables direct functionalization or derivatization, while the methyl ester provides synthetic versatility. This compound serves as a key building block in medicinal chemistry and agrochemical synthesis, particularly for bioactive heterocycles.
Methyl 2-hydroxy-4-(trifluoromethyl)benzoate serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient access to functionalized aromatic scaffolds. The ortho-hydroxyl group facilitates directed metalation and subsequent C–H functionalization, while the trifluoromethyl moiety imparts enhanced metabolic stability and lipophilicity. Its bench-stable nature and compatibility with common coupling and derivatization protocols make it ideal for sequential transformations in multi-step syntheses.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: