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CS-W001157 4
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5-Bromo-2,3-dihydro-1H-inden-1-ol

  • CAS No. 34598-50-0

  • Cat. No. CS-0035517
  • Purity≥97%
  • MDL No.MFCD06808667

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2,3-dihydro-1H-inden-1-ol|CS-0035517

Structure of 34598-50-0

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General Information

  • CAS No. 34598-50-0
  • Cat. No. CS-0035517
  • Purity ≥97%
  • MDL No. MFCD06808667
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉BrO
  • Molecular Weight 213.07
  • Synonym(s) BUTTPARK 91\15-77
  • SMILES C1CC(C2=CC=C(C=C12)Br)O

Description

5-Bromo-2,3-dihydro-1H-inden-1ol features a brominated indenol scaffold with a reactive hydroxyl group at C1. This bench-stable, moisture-tolerant compound serves as a key intermediate in synthetic routes to bioactive molecules, enabling efficient coupling and functionalization under mild conditions.

Application

5-Bromo-2,3-dihydro-1H-inden-1-ol serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted indene frameworks. Its bromine functionality supports palladium-catalyzed cross-coupling reactions, while the hydroxyl group offers orthogonal handling for derivatization or protection. The compound exhibits good bench stability and facilitates clean transformations under standard reaction conditions, making it well-suited for medicinal chemistry and process development workflows.

Synthesis

  • Route1

    References

    • Xue, Chu-Biao; Chen, Lihua; Cao, Ganfeng; Zhang, Ke; Wang, Anlai; Meloni, David; Glenn, Joseph; Anand, Rajan; Xia, Michael; Kong, Ling; Huang, Taisheng; Feng, Hao; Zheng, Changsheng; Li, Mei; Galya, Laurine; Zhou, Jiacheng; Shin, Niu; Baribaud, Fredric; Solomon, Kim; Scherle, Peggy; Zhao, Bitao; Diamond, Sharon; Emm, Tom; Keller, Douglas; Contel, Nancy; Yeleswaram, Swamy; Vaddi, Kris; Hollis, Gregory; Newton, Robert; Friedman, Steven; Metcalf, Brian ACS Medicinal Chemistry Letters, 2010 , vol. 1, # 9 p. 483 - 487

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.4287
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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