Lot numbers can be found on the outside label of a product:
Di-tert-Butyl carbonate
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CAS No. 34619-03-9
- Cat. No. CS-0146214
- Purity≥98%
- MDL No.None
*For research and further manufacturing use only, not for direct human use.
Structure of 34619-03-9
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General Information
- CAS No. 34619-03-9
- Cat. No. CS-0146214
- Purity ≥98%
- MDL No. None
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₉H₁₈O₃
- Molecular Weight 174.24
- Synonym(s) tert-butyl carbonate
- SMILES O=C(OC(C)(C)C)OC(C)(C)C
Description
Di-tert-butyl carbonate serves as a robust, bench-stable carbonylating agent for selective protection of amines and alcohols. This sterically hindered reagent enables efficient, low-temperature coupling under mild conditions, minimizing side reactions. Its stability simplifies handling and storage, while the tert-butyl groups facilitate clean deprotection via acidolysis.
Application
Di-tert-butyl carbonate serves as a robust, bench-stable carbamate protecting group reagent, enabling selective N-alkylation of amines under mild conditions. Its high functional group tolerance and ease of removal via acidolysis facilitate efficient synthesis of protected amino compounds. Widely employed in peptide chemistry and medicinal discovery, it functions as a reliable precursor for transient amine protection and orthogonal deprotection strategies.
Synthesis
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Route1
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In-stock
24424-99-5 -
125173-55-9 - ~%
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In-stock
34619-03-9
References
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Upjohn Company Patent: US5099019 A1, 1992 ;
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Route2
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111641-08-8
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In-stock
24424-99-5
- ~%
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In-stock
34619-03-9
References
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THE UPJOHN COMPANY Patent: EP263213 A1, 1988 ;
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References
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Held; Von Den Hoff; Stephenson; Zipse Advanced Synthesis and Catalysis, 2008 , vol. 350, # 11-12 p. 1891 - 1900
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 35.53
- LogP 2.7366
- H_Acceptors 3
- H_Donors 0
- Rotatable_Bonds 0
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