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Structure of 34636-92-5
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2-Methoxy-5-(trifluoromethyl)benzonitrile features a trifluoromethyl group that imparts strong electron-withdrawing character and enhanced metabolic stability, while the methoxy substituent provides moderate electron-donating effects. This balance enables efficient coupling in transition-metal-catalyzed reactions, particularly in Suzuki-Miyaura and Buchwald-Hartwig transformations. The molecule exhibits excellent bench stability and solubility in common organic solvents, facilitating straightforward handling during synthetic workflows.
2-Methoxy-5-(trifluoromethyl)benzonitrile serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient access to substituted benzimidazoles, benzoxazoles, and other heterocyclic scaffolds. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the methoxy and nitrile functionalities offer orthogonal reactivity for downstream functionalization. The compound exhibits excellent bench stability and is compatible with standard coupling and cyclization protocols.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 3439
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H302+H312-H315-H319-H331-H335
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Precautionary Statements : P264-P270-P330-P405-P501
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Lot numbers can be found on the outside label of a product: