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3-Chloro-4'-fluoropropiophenone

  • CAS No. 347-93-3

  • Cat. No. CS-0031428
  • Purity≥96%
  • MDL No.MFCD00000991

*For research and further manufacturing use only, not for direct human use.

3-Chloro-4'-fluoropropiophenone|CS-0031428

Structure of 347-93-3

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General Information

  • CAS No. 347-93-3
  • Cat. No. CS-0031428
  • Purity ≥96%
  • MDL No. MFCD00000991
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈ClFO
  • Molecular Weight 186.61
  • Synonym(s) 3-Chloro-4-fluoropropiophenone
  • SMILES O=C(CCCl)C1=CC=C(C=C1)F

Description

3-Chloro-4'-fluoropropiophenone features a strategically positioned chloro and fluoro substituent on the aromatic ring, enhancing electron-withdrawing effects and modulating reactivity. This configuration supports efficient coupling in synthetic transformations, particularly in pharmaceutical intermediates and functionalized building blocks requiring halogen-directed selectivity.

Application

3-Chloro-4'-fluoropropiophenone serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated aromatic ketones and heterocyclic scaffolds. Its orthogonal halogen functionality facilitates subsequent cross-coupling reactions, while the propiophenone backbone supports facile enolate derivatization. Bench-stable and compatible with standard purification protocols, it functions effectively in multistep syntheses requiring controlled reactivity and functional group tolerance.

Synthesis

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    • In-stock
      3-Chloro-4'-fluoropropiophenone|CS-0031428
      347-93-3

    References

    • J. Gen. Chem. USSR (Engl. Transl.), , vol. 37, p. 1233 - 1236,1169 - 1172 Canadian Journal of Research, , vol. 8, p. 440,444

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335-H412
Precautionary Statements : P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.6373
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   3

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