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CS-W001157 4
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8-Bromo-3-quinolinecarboxylic acid

  • CAS No. 347146-16-1

  • Cat. No. CS-0019156
  • Purity≥98%
  • MDL No.MFCD18375331
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

8-Bromo-3-quinolinecarboxylic acid|CS-0019156

Structure of 347146-16-1

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Description

8-Bromo-3-quinolinecarboxylic acid features a brominated quinoline scaffold with a carboxylic acid group at the 3-position, enabling direct coupling reactions. This electron-deficient heterocycle serves as a key building block for pharmaceutical intermediates and functional materials. The bromine moiety facilitates cross-coupling transformations, while the acidic functionality supports derivatization under standard conditions.

Application

8-Bromo-3-quinolinecarboxylic acid serves as a versatile building block for the synthesis of quinoline-based pharmaceutical intermediates and functional materials. The carboxylic acid group enables direct amidation, esterification, or coupling reactions, while the bromine substituent provides a reliable handle for palladium-catalyzed cross-coupling transformations. Its bench-stable nature and compatibility with standard synthetic protocols make it well-suited for iterative heterocycle construction and medicinal chemistry campaigns.

General Information

  • CAS No. 347146-16-1
  • Cat. No. CS-0019156
  • Purity ≥98%
  • MDL No. MFCD18375331
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₆BrNO₂
  • Molecular Weight 252.06
  • Synonym(s) 8-Bromoquinoline-3-carboxylic acid
  • SMILES O=C(C1=CC2=CC=CC(Br)=C2N=C1)O

Computational Chemistry Data

  • TPSA   50.19
  • LogP   2.6955
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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