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Structure of 348-25-4
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6-Fluoro-1H-indazole is a fluorinated heterocyclic scaffold featuring a nitrogen-rich core with enhanced electron-withdrawing character due to the para-fluorine substitution. This configuration improves metabolic stability and modulates lipophilicity, making it valuable for medicinal chemistry applications requiring optimized bioavailability and target engagement.
6-Fluoro-1H-indazole serves as a versatile heterocyclic building block in medicinal chemistry, enabling direct functionalization at the C6 position via palladium-catalyzed cross-coupling reactions. Its fluorinated aromatic core provides enhanced metabolic stability and modulated electronic properties, while maintaining excellent bench stability and compatibility with common reaction conditions. This compound functions effectively in the synthesis of kinase inhibitors and other bioactive scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302
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Precautionary Statements : P264-P270-P301+P310-P330-P501
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Lot numbers can be found on the outside label of a product: