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Structure of 348-28-7
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4-Fluorosalicylaldehyde features a fluorinated aromatic ring paired with adjacent aldehyde and hydroxyl groups, enabling robust coordination in metal complexes. The electron-withdrawing fluorine enhances electrophilicity at the carbonyl carbon, facilitating nucleophilic addition reactions. This bench-stable compound integrates readily into ligand frameworks for catalysis and materials synthesis.
4-Fluorosalicylaldehyde serves as a versatile building block in medicinal chemistry and materials science, enabling efficient synthesis of bioactive heterocycles and functionalized aromatics. Its ortho-hydroxy and aldehyde functionalities facilitate direct condensation reactions, chelation, and metal coordination, while the fluorine substituent enhances metabolic stability and modulates electronic properties. The compound exhibits excellent bench stability and compatibility with standard purification techniques, making it ideal for iterative synthetic workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: