1-Bromo-2,4-difluorobenzene

Name: 1-Bromo-2,4-difluorobenzene
Brand: ChemScene
Availability: InStock
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CAS No. 348-57-2
Cat. No. CS-W010697
Purity≥98%
MDL No.MFCD00000330

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 348-57-2

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Description

1-Bromo-2,4-difluorobenzene is a fluorinated aryl halide featuring strategically positioned bromine and two fluorine substituents on a benzene ring. This electron-deficient aromatic system enables efficient coupling reactions in cross-coupling protocols. The molecule exhibits enhanced stability under standard conditions and offers predictable regioselectivity in palladium-catalyzed transformations.

Application

1-Bromo-2,4-difluorobenzene serves as a versatile building block in cross-coupling chemistry, enabling the synthesis of substituted biaryls and heterocycles under palladium catalysis. The ortho-fluorine facilitates directed metalation, while the bromine supports efficient coupling reactions. Its bench-stable nature and compatibility with diverse functional groups make it ideal for medicinal chemistry and process development workflows.

General Information

CAS No. 348-57-2
Cat. No. CS-W010697
Purity ≥98%
MDL No. MFCD00000330
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₃BrF₂
Molecular Weight 192.99
Synonym(s) 2,4-Difluorobromobenzene
SMILES FC1=CC=C(Br)C(F)=C1

Computational Chemistry Data

TPSA 0
LogP 2.7273
H_Acceptors 0
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS02,GHS07
Signal Word : Danger	UN#: 1993
Class : 3	Packing Group : Ⅲ
Hazard Statements : H226-H315-H319-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P362-P370+P378-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Chemical Synthesis Synthetic Reagents Aryne Precursors, Heteroaryne Precursors Benzyne Precursors

Key Words

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1-Bromo-2,4-difluorobenzene

CAS No. 348-57-2

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