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CS-W001157 4
Total: USD 88.00

1-Bromo-2,4-difluorobenzene

  • CAS No. 348-57-2

  • Cat. No. CS-W010697
  • Molecule weight192.99
  • Purity≥98%
  • MDL No.MFCD00000330

*For research and further manufacturing use only, not for direct human use.

1-Bromo-2,4-difluorobenzene|CS-W010697

Structure of 348-57-2

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General Information

  • CAS No. 348-57-2
  • Cat. No. CS-W010697
  • Purity ≥98%
  • MDL No. MFCD00000330
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrF₂
  • Molecular Weight 192.99
  • Synonym(s) 2,4-Difluorobromobenzene
  • SMILES FC1=CC=C(Br)C(F)=C1

Description

1-Bromo-2,4-difluorobenzene is a fluorinated aryl halide featuring strategically positioned bromine and two fluorine substituents on a benzene ring. This electron-deficient aromatic system enables efficient coupling reactions in cross-coupling protocols. The molecule exhibits enhanced stability under standard conditions and offers predictable regioselectivity in palladium-catalyzed transformations.

Application

1-Bromo-2,4-difluorobenzene serves as a versatile building block in cross-coupling chemistry, enabling the synthesis of substituted biaryls and heterocycles under palladium catalysis. The ortho-fluorine facilitates directed metalation, while the bromine supports efficient coupling reactions. Its bench-stable nature and compatibility with diverse functional groups make it ideal for medicinal chemistry and process development workflows.

Synthesis

  • Route1
    • null|null
      372-18-9
    • ~%
    • In-stock
      1-Bromo-2,4-difluorobenzene|CS-W010697
      348-57-2

    References

    • Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , p. 71,73; engl. Ausg. S. 64, 66
  • Route2

    References

    • European Journal of Organic Chemistry, , # 23 p. 4618 - 4624
  • Route3
    • (2,4-Difluorophenyl)trimethylsilane|CS-0320904
      148854-10-8
    • ~37%
    • In-stock
      1-Bromo-2,4-difluorobenzene|CS-W010697
      348-57-2

    References

    • Coe, Paul L.; Stuart, Alison M.; Moody, David J. Journal of Fluorine Chemistry, 1998 , vol. 92, # 1 p. 27 - 32

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226-H315-H319-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P362-P370+P378-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   2.7273
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   0

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