4-Chloro-2-fluorophenol

Name: 4-Chloro-2-fluorophenol
Brand: ChemScene
Availability: InStock
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CAS No. 348-62-9
Cat. No. CS-W007711
Purity≥97%
MDL No.MFCD00075030

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 348-62-9

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Description

4-Chloro-2-fluorophenol features a fluorine atom at the ortho position relative to the hydroxyl group, enhancing its electron-withdrawing character and metabolic stability. This substitution pattern imparts favorable reactivity in electrophilic aromatic substitution and facilitates coupling reactions under mild conditions. The compound serves as a key intermediate in agrochemical and pharmaceutical synthesis due to its balanced polarity and structural rigidity.

Application

4-Chloro-2-fluorophenol serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the phenolic OH and ortho-position via electrophilic substitution or transition-metal-catalyzed coupling. Its halogenated aryl scaffold offers excellent compatibility with Suzuki, Stille, and Buchwald-Hartwig reactions, facilitating rapid access to complex heterocycles and bioactive intermediates. The compound exhibits robust bench stability and straightforward purification, making it ideal for high-throughput synthesis and process development.

General Information

CAS No. 348-62-9
Cat. No. CS-W007711
Purity ≥97%
MDL No. MFCD00075030
Storage RT, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₄ClFO
Molecular Weight None
Synonym(s) 4,4,4-trifluoro-3-methylbutanoic acid
SMILES OC1=CC=C(Cl)C=C1F

Computational Chemistry Data

TPSA 20.23
LogP 2.1847
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352

Quality Control

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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4-Chloro-2-fluorophenol

CAS No. 348-62-9

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