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CS-W001157 4
Total: USD 88.00

1-[3-(Trifluoromethyl)phenyl]-1-ethanone

  • CAS No. 349-76-8

  • Cat. No. CS-W019972
  • Purity≥96%
  • MDL No.MFCD00000391
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1-[3-(Trifluoromethyl)phenyl]-1-ethanone|CS-W019972

Structure of 349-76-8

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Description

Used in perfumery to give power, lift, and freshness. For use in toothpaste, cough drops, mouthwash, ice cream, chewing gum, tobacco, medical plaster, tonic, and shampoos. Because of its cooling action, it is to be found in a wide range of medicines treating sore throats and mouth irritations. It is also used in treatments for minor aches and sprains, and in nasal decongestants. It is found in some oral hygiene products to combat bad breath. Of course, it is present in a number of chewing gums. It was first added to cigarettes in the 1920s and 1930s (e.g. Spud and Kool brands) for both its flavor and also to reduce irritation, especially to the throat.

Application

1-[3-(Trifluoromethyl)phenyl]-1-ethanone serves as a valuable building block in medicinal chemistry, enabling the synthesis of biologically active aryl ketones. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the ketone functionality offers direct access to secondary alcohols, enol ethers, and heterocycles via standard transformations. The compound exhibits good bench stability and is compatible with common functional group manipulations, facilitating efficient route design in API development.

General Information

  • CAS No. 349-76-8
  • Cat. No. CS-W019972
  • Purity ≥96%
  • MDL No. MFCD00000391
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇F₃O
  • Molecular Weight 188.15
  • Synonym(s) 1-[5-(Trifluoromethyl)phenyl]ethanone; 3-Trifluoromethyl-1-acetylbenzene; m-(Trifluoromethyl)acetophenone
  • SMILES CC(C1=CC=CC(C(F)(F)F)=C1)=O

Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.908
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H227-H315-H319-H335
Precautionary Statements : P210-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P403-P405-P501

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