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CS-W001157 4
Total: USD 88.00

4-Fluorobenzenesulfonyl chloride

  • CAS No. 349-88-2

  • Cat. No. CS-W008916
  • Purity≥97%
  • MDL No.MFCD00007438
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Fluorobenzenesulfonyl chloride|CS-W008916

Structure of 349-88-2

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Description

4-Fluorobenzenesulfonyl chloride delivers a highly reactive sulfonylating agent featuring a fluorinated aromatic ring that enhances electrophilicity and improves solubility in organic solvents. This bench-stable reagent enables efficient formation of sulfonamide and sulfonate derivatives under mild conditions, offering enhanced selectivity in complex molecular architectures.

Application

4-Fluorobenzenesulfonyl chloride serves as a reliable sulfonylating agent for the synthesis of sulfonamide derivatives, offering high reactivity with amines and alcohols under mild conditions. Its fluorinated aryl group enhances stability and facilitates purification via crystallization or chromatography. The compound functions effectively in the construction of bioactive scaffolds and is compatible with diverse functional groups, making it a practical choice for medicinal chemistry and process development workflows.

General Information

  • CAS No. 349-88-2
  • Cat. No. CS-W008916
  • Purity ≥97%
  • MDL No. MFCD00007438
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄ClFO₂S
  • Molecular Weight 194.61
  • Synonym(s) 4-Fluorobenzene-1-sulfonyl chloride; 4-Fluorophenylsulfonyl chloride
  • SMILES O=S(C1=CC=C(F)C=C1)(Cl)=O

Computational Chemistry Data

  • TPSA   34.14
  • LogP   1.7532
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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