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Structure of 349-97-3
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N-(4-(Trifluoromethyl)phenyl)acetamide features a trifluoromethyl-substituted phenyl ring paired with an acetamide linkage, delivering enhanced electron-withdrawing character and improved metabolic stability. This combination enables robust integration into pharmaceutical scaffolds and facilitates efficient coupling in synthetic workflows under standard conditions.
N-(4-(Trifluoromethyl)phenyl)acetamide serves as a versatile building block in medicinal chemistry, enabling efficient access to functionalized aryl amides through standard coupling and reduction protocols. Its trifluoromethyl group imparts enhanced metabolic stability and lipophilicity, while the acetamide moiety offers predictable reactivity in amide bond formation and derivatization. Bench-stable and readily purified by recrystallization, it functions reliably in multistep synthesis of bioactive scaffolds and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H332-H335
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Precautionary Statements : P233-P260-P261-P264-P270-P271-P280-P302+P352-P304+P340-P340-P362-P403-P405-P501
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Lot numbers can be found on the outside label of a product: