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Structure of 35046-68-5
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Tetramethylsuccinic anhydride features a sterically hindered anhydride core that enhances hydrolytic stability and enables selective acylation under mild conditions. This bench-stable reagent integrates efficiently into synthetic workflows requiring controlled functionalization of nucleophiles, particularly in peptide modification and polymer chemistry.
Tetramethylsuccinic anhydride serves as a sterically hindered acylating agent, enabling efficient amidation and esterification under mild conditions. Its four methyl groups confer enhanced stability and solubility in organic solvents, facilitating clean reactions with amines and alcohols. The resulting derivatives are readily purified by chromatography or crystallization, making it a practical choice for synthesizing protected amino acids, peptide analogs, and functionalized building blocks in medicinal chemistry workflows.
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GHS No : GHS05,GHS07,GHS08
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅱ
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Hazard Statements : H302-H314-H317-H334-H335
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Precautionary Statements : P260-P261-P264-P270-P271-P272-P280-P284-P301+P330+P331-P302+P352-P304+P340-P330-P362+P364-P363-P405-P501
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Lot numbers can be found on the outside label of a product: