2-Chloro-N-(4-fluorophenyl)acetamide

Name: 2-Chloro-N-(4-fluorophenyl)acetamide
Brand: ChemScene
Availability: InStock
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CAS No. 351-04-2
Cat. No. CS-0072599
Purity≥97%
MDL No.MFCD00015730

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-N-(4-fluorophenyl)acetamide|CS-0072599

Structure of 351-04-2

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Description

2-Chloro-N-(4-fluorophenyl)acetamide is a bench-stable, moisture-tolerant amide featuring a chlorinated acetyl group linked to a fluorinated phenyl ring. This electron-deficient aryl scaffold enables efficient coupling reactions and serves as a key intermediate in the synthesis of bioactive compounds.

Application

2-Chloro-N-(4-fluorophenyl)acetamide serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated aromatic amides. Its stability under standard reaction conditions and compatibility with common coupling protocols facilitate straightforward incorporation into complex scaffolds. The chloroacetamide moiety functions as a reactive handle for nucleophilic substitution and participates in key transformations during API synthesis.

General Information

CAS No. 351-04-2
Cat. No. CS-0072599
Purity ≥97%
MDL No. MFCD00015730
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₇ClFNO
Molecular Weight None
Synonym(s) 2-Chloro-4-Fluoroacetanilide
SMILES O=C(CCl)NC(C=C1)=CC=C1F

Computational Chemistry Data

TPSA 29.1
LogP 2.003
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Amide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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2-Chloro-N-(4-fluorophenyl)acetamide

CAS No. 351-04-2

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