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Structure of 351003-02-6
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5-Bromo-2-methylnicotinic acid features a bromine substituent at the 5-position and a methyl group at the 2-position on the pyridine ring, delivering enhanced electron-withdrawing character and steric influence. This combination enables efficient coupling in cross-coupling reactions and facilitates incorporation into bioactive heterocycles under standard conditions.
5-Bromo-2-methylnicotinic acid serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its brominated pyridine core enables palladium-catalyzed cross-coupling reactions, while the carboxylic acid and methyl groups offer orthogonal functionalization potential. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthetic workflows in medicinal chemistry and process development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: