4-(Difluoromethoxy)benzene-1-sulfonyl chloride

Name: 4-(Difluoromethoxy)benzene-1-sulfonyl chloride
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 351003-34-4
Cat. No. CS-0072600
Purity≥97%
MDL No.None

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-(Difluoromethoxy)benzene-1-sulfonyl chloride|CS-0072600

Structure of 351003-34-4

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 351003-34-4
Cat. No. CS-0072600
Purity ≥97%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₅ClF₂O₃S
Molecular Weight 242.63
Synonym(s) 4-(Difluoromethoxy)benzenesulfonyl chloride
SMILES O=S(C(C=C1)=CC=C1OC(F)F)(Cl)=O

Description

4-(Difluoromethoxy)benzene-1-sulfonyl chloride features a difluoromethoxy group attached to a benzene ring, which enhances lipophilicity and metabolic stability. The sulfonyl chloride moiety enables efficient coupling reactions, facilitating the introduction of sulfonamide functionalities in medicinal chemistry applications. This reagent is bench-stable under standard conditions and exhibits high reactivity with amines and alcohols.

Application

4-(Difluoromethoxy)benzene-1-sulfonyl chloride serves as a versatile sulfonylating agent for the synthesis of sulfonamide derivatives. Its difluoromethoxy group enhances metabolic stability and modulates lipophilicity, making it valuable in medicinal chemistry workflows. The reagent exhibits good bench stability and reacts efficiently with primary and secondary amines under mild conditions, enabling straightforward access to functionalized sulfonamides with high purity and predictable yields.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3265
Class : 8	Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 43.37
LogP 2.2155
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 3

Other Classifications

Building Blocks Functional Group Sulfonyl Chloride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

351003-34-4 sigma351003-34-4 manufacturer351003-34-4 price351003-34-4 structure351003-34-4 SDSbuy 351003-34-4351003-34-4 supplier351003-34-4 uses351003-34-4 molecular weightprice of 351003-34-4351003-34-4 chemical name formula of 351003-34-4

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

4-(Difluoromethoxy)benzene-1-sulfonyl chloride

CAS No. 351003-34-4

Recommended Products