4-(Difluoromethoxy)benzene-1-sulfonyl chloride

Name: 4-(Difluoromethoxy)benzene-1-sulfonyl chloride
Brand: ChemScene
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CAS No. 351003-34-4
Cat. No. CS-0072600
Purity≥97%
MDL No.None

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4-(Difluoromethoxy)benzene-1-sulfonyl chloride|CS-0072600

Structure of 351003-34-4

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Description

4-(Difluoromethoxy)benzene-1-sulfonyl chloride features a difluoromethoxy group attached to a benzene ring, which enhances lipophilicity and metabolic stability. The sulfonyl chloride moiety enables efficient coupling reactions, facilitating the introduction of sulfonamide functionalities in medicinal chemistry applications. This reagent is bench-stable under standard conditions and exhibits high reactivity with amines and alcohols.

Application

4-(Difluoromethoxy)benzene-1-sulfonyl chloride serves as a versatile sulfonylating agent for the synthesis of sulfonamide derivatives. Its difluoromethoxy group enhances metabolic stability and modulates lipophilicity, making it valuable in medicinal chemistry workflows. The reagent exhibits good bench stability and reacts efficiently with primary and secondary amines under mild conditions, enabling straightforward access to functionalized sulfonamides with high purity and predictable yields.

General Information

CAS No. 351003-34-4
Cat. No. CS-0072600
Purity ≥97%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₅ClF₂O₃S
Molecular Weight 242.63
Synonym(s) 4-(Difluoromethoxy)benzenesulfonyl chloride
SMILES O=S(C(C=C1)=CC=C1OC(F)F)(Cl)=O

Computational Chemistry Data

TPSA 43.37
LogP 2.2155
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 3

Safety Information

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GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3265
Class : 8	Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Other Classifications

Building Blocks Functional Group Sulfonyl Chloride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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4-(Difluoromethoxy)benzene-1-sulfonyl chloride

CAS No. 351003-34-4

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