Lot numbers can be found on the outside label of a product:
5-Bromo-4-methylnicotinaldehyde
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CAS No. 351457-86-8
- Cat. No. CS-W022330
- Purity≥97%
- MDL No.MFCD09909851
*For research and further manufacturing use only, not for direct human use.
Structure of 351457-86-8
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General Information
- CAS No. 351457-86-8
- Cat. No. CS-W022330
- Purity ≥97%
- MDL No. MFCD09909851
- Storage 4°C, stored under nitrogen
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₇H₆BrNO
- Molecular Weight 200.03
- Synonym(s) 5-Bromo-4-methyl-pyridine-3-carbaldehyde
- SMILES O=CC1=CN=CC(Br)=C1C
Description
5-Bromo-4-methylnicotinaldehyde delivers a reactive aldehyde group flanked by a bromine atom and a methyl substituent on the pyridine ring. This electronic and steric configuration enables direct coupling in cross-coupling reactions, facilitating rapid access to functionalized heterocycles under standard conditions.
Application
5-Bromo-4-methylnicotinaldehyde serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted pyridine scaffolds via cross-coupling and condensation reactions. The aldehyde functionality facilitates direct functionalization or imine formation, while the bromo group supports palladium-catalyzed coupling processes. Bench-stable and compatible with diverse reaction conditions, it functions effectively in medicinal chemistry campaigns targeting heterocyclic lead compounds.
Synthesis
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Route1
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In-stock
3430-23-7 -
68-12-2 - ~71%
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In-stock
351457-86-8
References
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PFIZER INC., Patent: WO2006/54151 A1, 2006 ; Location in patent: Page/Page column 8 ;
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Route2
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68-12-2
- ~%
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In-stock
351457-86-8
References
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SANOFI-AVENTIS Patent: US2006/4000 A1, 2006 ; Location in patent: Page/Page column 15 ;
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Route3
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In-stock
69321-60-4 -
68-12-2
- ~%
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In-stock
351457-86-8
References
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NOVARTIS AG; ASTEX THERAPEUTICS LIMITED; HOWARD, Steven; MORTENSON, Paul Neil; HISCOCK, Steven Douglas; WOOLFORD, Alison Jo-Anne; WOODHEAD, Andrew James; CHESSARI, Gianni; O'REILLY, Marc; CONGREVE, Miles Stuart; DAGOSTIN, Claudio; CHO, Young Shin; YANG, Fan; CHEN, Christine Hiu-Tung; BRAIN, Christopher Thomas; LAGU, Bharat; WANG, Yaping; KIM, Sunkyu; GRIALDES, John; LUZZIO, Michael Joseph; PEREZ, Lawrence Blas Patent: WO2010/125402 A1, 2010 ; Location in patent: Page/Page column 121-122 ; WO 2010/125402 A1
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 29.96
- LogP 1.96502
- H_Acceptors 2
- H_Donors 0
- Rotatable_Bonds 1
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Key Words
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