6-Chloro-5-nitropicolinic acid

Name: 6-Chloro-5-nitropicolinic acid
Brand: ChemScene
Availability: InStock
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CAS No. 353277-27-7
Cat. No. CS-W006408
Purity≥95%
MDL No.MFCD01927937

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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6-Chloro-5-nitropicolinic acid|CS-W006408

Structure of 353277-27-7

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Description

6-Chloro-5-nitropicolinic acid features a sterically constrained pyridine core bearing chlorine and nitro groups at adjacent positions, enhancing its utility in transition metal-catalyzed coupling reactions. The electron-deficient aromatic system facilitates efficient C–H functionalization and serves as a robust scaffold for pharmaceutical and agrochemical intermediates. This bench-stable derivative exhibits improved solubility in polar organic solvents, streamlining handling during synthetic workflows.

Application

6-Chloro-5-nitropicolinic acid serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C6 position via palladium-catalyzed cross-coupling. The nitro group facilitates subsequent reduction and cyclization strategies, while the carboxylic acid provides a handle for amide coupling or esterification. Its bench-stable crystalline form and compatibility with standard synthetic workflows make it ideal for constructing heterocyclic scaffolds and API intermediates.

General Information

CAS No. 353277-27-7
Cat. No. CS-W006408
Purity ≥95%
MDL No. MFCD01927937
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₃ClN₂O₄
Molecular Weight 202.55
Synonym(s) None
SMILES O=C(O)C1=NC(Cl)=C([N+]([O-])=O)C=C1

Computational Chemistry Data

TPSA 93.33
LogP 1.3414
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Functional Group Nitro compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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6-Chloro-5-nitropicolinic acid

CAS No. 353277-27-7

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