Lot numbers can be found on the outside label of a product:
2-Chloro-3-nitropyridine-4-carboxylic acid
-
CAS No. 353281-15-9
- Cat. No. CS-0051971
- Purity≥98%
- MDL No.None
*For research and further manufacturing use only, not for direct human use.
Structure of 353281-15-9
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 353281-15-9
- Cat. No. CS-0051971
- Purity ≥98%
- MDL No. None
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₆H₃ClN₂O₄
- Molecular Weight 202.55
- Synonym(s) 2-Chloro-3-nitropyridine-4-carboxylic acid
- SMILES OC(=O)C1=C(C(Cl)=NC=C1)[N+]([O-])=O
Description
2-Chloro-3-nitroisonicotinic acid features a strategically positioned chloro group and electron-deficient nitro moiety on the pyridine ring, enabling direct incorporation into heterocyclic scaffolds. This bench-stable derivative delivers enhanced reactivity in cross-coupling and cyclization processes under standard conditions.
Application
2-Chloro-3-nitroisonicotinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of substituted isonicotinamide scaffolds through amide coupling or nucleophilic displacement. Its ortho-chloro and meta-nitro groups provide complementary reactivity for sequential functionalization, with good bench stability and straightforward purification via recrystallization. The molecule functions effectively in standard cross-coupling and heterocycle formation protocols, offering reliable access to bioactive intermediates in API development.
Synthesis
-
Route1
-
In-stock
23056-39-5 - ~%
-
In-stock
353281-15-9
References
-
Beijing Yiling Bioengineering Co., Ltd. Patent: EP2366691 A1, 2011 ; Location in patent: Page/Page column 7-8 ;
-
-
Route2
-
In-stock
6635-86-5 - ~%
-
In-stock
353281-15-9
References
-
Beijing Yiling Bioengineering Co., Ltd. Patent: EP2366691 A1, 2011 ;
-
-
Route3
-
In-stock
21901-18-8 - ~%
-
In-stock
353281-15-9
References
-
Beijing Yiling Bioengineering Co., Ltd. Patent: EP2366691 A1, 2011 ;
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H302-H315-H319-H335
|
|
|
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 93.33
- LogP 1.3414
- H_Acceptors 4
- H_Donors 1
- Rotatable_Bonds 2
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- 353281-15-9 sigma353281-15-9 manufacturer353281-15-9 price353281-15-9 structure353281-15-9 SDSbuy 353281-15-9353281-15-9 supplier353281-15-9 uses353281-15-9 molecular weightprice of 353281-15-9353281-15-9 chemical name formula of 353281-15-9