2-Chloro-3-nitropyridine-4-carboxylic acid

Name: 2-Chloro-3-nitropyridine-4-carboxylic acid
Brand: ChemScene
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CAS No. 353281-15-9
Cat. No. CS-0051971
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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2-Chloro-3-nitropyridine-4-carboxylic acid|CS-0051971

Structure of 353281-15-9

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Description

2-Chloro-3-nitroisonicotinic acid features a strategically positioned chloro group and electron-deficient nitro moiety on the pyridine ring, enabling direct incorporation into heterocyclic scaffolds. This bench-stable derivative delivers enhanced reactivity in cross-coupling and cyclization processes under standard conditions.

Application

2-Chloro-3-nitroisonicotinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of substituted isonicotinamide scaffolds through amide coupling or nucleophilic displacement. Its ortho-chloro and meta-nitro groups provide complementary reactivity for sequential functionalization, with good bench stability and straightforward purification via recrystallization. The molecule functions effectively in standard cross-coupling and heterocycle formation protocols, offering reliable access to bioactive intermediates in API development.

General Information

CAS No. 353281-15-9
Cat. No. CS-0051971
Purity ≥98%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₃ClN₂O₄
Molecular Weight 202.55
Synonym(s) 2-Chloro-3-nitropyridine-4-carboxylic acid
SMILES OC(=O)C1=C(C(Cl)=NC=C1)[N+]([O-])=O

Computational Chemistry Data

TPSA 93.33
LogP 1.3414
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Functional Group Nitro compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Chloro-3-nitropyridine-4-carboxylic acid

CAS No. 353281-15-9

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