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CS-W001157 4
Total: USD 88.00

4-(4-Bromophenyl)butanoic acid

  • CAS No. 35656-89-4

  • Cat. No. CS-0009030
  • Purity≥96%
  • MDL No.MFCD00463170

*For research and further manufacturing use only, not for direct human use.

4-(4-Bromophenyl)butanoic acid|CS-0009030

Structure of 35656-89-4

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General Information

  • CAS No. 35656-89-4
  • Cat. No. CS-0009030
  • Purity ≥96%
  • MDL No. MFCD00463170
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₁BrO₂
  • Molecular Weight 243.10
  • Synonym(s) benzenebutanoic acid, 4-bromo-
  • SMILES BrC1=CC=C(CCCC(O)=O)C=C1

Description

4-(4-Bromophenyl)butanoic acid features a conjugated aryl-alkyl chain enabling efficient integration into bioactive scaffolds. The para-brominated phenyl group provides a handle for palladium-catalyzed cross-coupling, while the carboxylic acid moiety facilitates derivatization. This compound exhibits robust stability under standard conditions and is compatible with diverse synthetic workflows.

Application

4-(4-Bromophenyl)butanoic acid serves as a versatile building block for constructing pharmaceutically relevant arylalkyl scaffolds. Its brominated aromatic ring enables facile cross-coupling reactions, while the carboxylic acid group facilitates derivatization via amide formation, esterification, or salt generation. The compound exhibits good bench stability and is readily purified by recrystallization, supporting its utility in medicinal chemistry campaigns and process development workflows.

Synthesis

  • Route1

    References

    • Sommer; Rheingold; Goshe; Bosnich Journal of the American Chemical Society, 2001 , vol. 123, # 17 p. 3940 - 3952
  • Route2
    • null|null
      108-86-1
    • ~%
    • In-stock
      4-(4-Bromophenyl)butanoic acid|CS-0009030
      35656-89-4

    References

    • Journal of the American Chemical Society, , vol. 123, # 17 p. 3940 - 3952
  • Route3
    • 1-Allyl-4-bromobenzene|CS-0464852
      2294-43-1
    • ~%
    • In-stock
      4-(4-Bromophenyl)butanoic acid|CS-0009030
      35656-89-4

    References

    • Organic Letters, , vol. 13, # 5 p. 1086 - 1088

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.8564
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   4

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