Dimethoxy(methyl)(3,3,3-trifluoropropyl)silane

Name: Dimethoxy(methyl)(3,3,3-trifluoropropyl)silane
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 358-67-8
Cat. No. CS-0150977
Molecule weight202.25
Purity≥95%
MDL No.MFCD00053175

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Dimethoxy(methyl)(3,3,3-trifluoropropyl)silane|CS-0150977

Structure of 358-67-8

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 358-67-8
Cat. No. CS-0150977
Purity ≥95%
MDL No. MFCD00053175
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₁₃F₃O₂Si
Molecular Weight 202.25
Synonym(s) 1,1,1-Trifluoro-3-[dimethoxy(methyl)silyl]propane
SMILES CO[Si](C)(CCC(F)(F)F)OC

Description

Dimethoxy(methyl)(3,3,3-trifluoropropyl)silane features a trifluoropropyl group that imparts enhanced hydrophobicity and thermal stability. The methoxy groups enable efficient hydrolysis and condensation under mild conditions, facilitating robust siloxane network formation. This reagent integrates readily into hybrid organic-inorganic materials, offering improved moisture resistance and durability in coatings and adhesives.

Application

Dimethoxy(methyl)(3,3,3-trifluoropropyl)silane serves as a versatile silyl protecting group reagent, enabling selective protection of alcohols and amines under mild conditions. Its trifluoropropyl moiety enhances lipophilicity and metabolic stability, while the dimethoxy group facilitates efficient hydrolysis for deprotection. The methyl substituent improves steric control and reaction selectivity. This reagent functions reliably in multi-step synthesis workflows, offering bench-stable handling, clean reaction profiles, and compatibility with diverse functional groups.

Synthesis

Route1
- 67-56-1
- 675-62-7
- ~54%
- In-stock
  
  358-67-8
References
- Ladilina; Lyubova; Semenov; Kurskii; Kuznetsova Russian Chemical Bulletin, 2009 , vol. 58, # 5 p. 1015 - 1022
Route2
- 1185-55-3
- 461-21-2
- ~%
- In-stock
  
  358-67-8
References
- Journal of the American Chemical Society, , vol. 77, p. 1292

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS02
Signal Word : Danger	UN#: 1993
Class : 3	Packing Group : Ⅲ
Hazard Statements : H225
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P370+P378-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 18.46
LogP 2.3036
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 4

Other Classifications

Building Blocks Functional Group Organosilicon compounds

Building Blocks Skeleton Fatty chain compounds

Material Science Electronic Materials Self assembly and contact printing materials

Material Science Organic-Inorganic Hybrid Materials A silane coupling agent

Material Science Electronic Materials Self Assembly Materials, Contact Printing Materials Silane Coupling Agents/Adhesion Promoters

Chemical Synthesis Organometallic Reagents Organosilicon Organosilicon Compounds (Other)

Key Words

358-67-8 sigma358-67-8 manufacturer358-67-8 price358-67-8 structure358-67-8 SDSbuy 358-67-8358-67-8 supplier358-67-8 uses358-67-8 molecular weightprice of 358-67-8358-67-8 chemical name formula of 358-67-8

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

Dimethoxy(methyl)(3,3,3-trifluoropropyl)silane

CAS No. 358-67-8

Recommended Products