Lot numbers can be found on the outside label of a product:
1-BOC-5-Methyl-3-pyrrolidinone
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CAS No. 362706-25-0
- Cat. No. CS-W019809
- Purity≥98%
- MDL No.MFCD22376634
*For research and further manufacturing use only, not for direct human use.
Structure of 362706-25-0
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General Information
- CAS No. 362706-25-0
- Cat. No. CS-W019809
- Purity ≥98%
- MDL No. MFCD22376634
- Storage -20°C, sealed storage, away from moisture
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₀H₁₇NO₃
- Molecular Weight 199.25
- Synonym(s) tert-Butyl 2-methyl-4-oxopyrrolidine-1-carboxylate
- SMILES O=C(N1C(C)CC(C1)=O)OC(C)(C)C
Description
1-BOC-5-Methyl-3-pyrrolidinone features a protected pyrrolidinone core with a sterically hindered BOC group, enabling stable incorporation into complex molecular architectures. This bench-stable derivative facilitates efficient synthesis of bioactive heterocycles and pharmaceutical intermediates under standard conditions.
Application
1-BOC-5-Methyl-3-pyrrolidinone serves as a versatile pyrrolidinone building block in medicinal chemistry, enabling efficient synthesis of nitrogen-containing heterocycles. The BOC group provides stable protection of the amine functionality under standard reaction conditions, facilitating subsequent transformations such as nucleophilic substitutions and reductive cleavage. Its methyl substituent enhances lipophilicity and structural diversity in target scaffolds, while the cyclic lactam framework supports orthogonal functionalization for complex molecule assembly.
Synthesis
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Route1
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23770-07-2 -
In-stock
24424-99-5 - ~65%
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In-stock
362706-25-0
References
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GLAXOSMITHKLINE LLC; CHRISTENSEN, Siegfried, Benjamin, IV; QIN, Donghui; CHEN, Shenglin; HUANG, Xing; LI, Di; LI, Fei; LI, Lei; LIN, Xiaojuan; LU, Shi; LU, Zhen; LV, Maoyun; WANG, Chuanning; WU, Chengde; XIAO, Mei; YU, Haiyu; ZHANG, Weina; ZHANG, Zhiliu Patent: WO2010/141539 A1, 2010 ; Location in patent: Page/Page column 24-25 ;
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Route2
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156865-72-4 - ~%
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In-stock
362706-25-0
References
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NOVARTIS AG; DILLON, Michael, Patrick; LINDVALL, Mika; POON, Daniel; RAMURTHY, Savithri; RAUNIYAR, Vivek; SHAFER, Cynthia; SUBRAMANIAN, Sharadha; TANNER, Huw Patent: WO2014/47020 A1, 2014 ; Location in patent: Page/Page column 84 ;
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Route3
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In-stock
897046-42-3 - ~%
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In-stock
362706-25-0
References
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NOVARTIS AG; DILLON, Michael, Patrick; LINDVALL, Mika; POON, Daniel; RAMURTHY, Savithri; RAUNIYAR, Vivek; SHAFER, Cynthia; SUBRAMANIAN, Sharadha; TANNER, Huw Patent: WO2014/47020 A1, 2014 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 46.61
- LogP 1.5848
- H_Acceptors 3
- H_Donors 0
- Rotatable_Bonds 0
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Key Words
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