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CS-W001157 4
Total: USD 88.00

1,1,3,3-Tetramethyl-2-(2-oxopyridin-1(2H)-yl)isouronium hexafluorophosphate

  • CAS No. 364047-51-8

  • Cat. No. CS-0372189
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1,1,3,3-Tetramethyl-2-(2-oxopyridin-1(2H)-yl)isouronium hexafluorophosphate|CS-0372189

Structure of 364047-51-8

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General Information

  • CAS No. 364047-51-8
  • Cat. No. CS-0372189
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₆F₆N₃O₂P
  • Molecular Weight 355.22
  • Synonym(s) (DiMethylaMino)-N,N-diMethyl[(2-oxo-1(2H)-pyridinyl)oxy]MethaniMiniuM hexafluorophosphate
  • SMILES O=C1C=CC=CN1O/C(N(C)C)=[N+](C)/C.[F-][P+5]([F-])([F-])([F-])([F-])[F-]

Description

This isouronium reagent features a pyridinone-bearing electrophilic center paired with a hexafluorophosphate counterion, enabling efficient coupling under mild conditions. The tetramethyl substitution enhances solubility and stability, while the 2-oxopyridin-1(2H)-yl group facilitates rapid reaction kinetics in amide bond formation.

Application

1,1,3,3-Tetramethyl-2-(2-oxopyridin-1(2H)-yl)isouronium hexafluorophosphate serves as a highly effective reagent for amide and peptide bond formation under mild conditions. Its pyridone-based isourea structure enables rapid coupling with carboxylic acids, offering excellent functional group tolerance and clean byproduct formation. The reagent exhibits superior bench stability and ease of purification, making it well-suited for high-throughput synthesis and scale-up in medicinal chemistry and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H314
Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P330-P363-P405-P501

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Computational Chemistry Data

  • TPSA   N/A
  • LogP   N/A
  • H_Acceptors   N/A
  • H_Donors   N/A
  • Rotatable_Bonds   N/A

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