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CS-W001157 4
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4-(2-Chloroethyl)morpholine hydrochloride

  • CAS No. 3647-69-6

  • Cat. No. CS-0015128
  • Purity≥97%
  • MDL No.MFCD00012797
  • AREC Toxic Substance

*For research and further manufacturing use only, not for direct human use.

4-(2-Chloroethyl)morpholine hydrochloride|CS-0015128

Structure of 3647-69-6

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General Information

  • CAS No. 3647-69-6
  • Cat. No. CS-0015128
  • Purity ≥97%
  • MDL No. MFCD00012797
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₃Cl₂NO
  • Molecular Weight 186.08
  • Synonym(s) N-(2-Chloroethyl)Morpholine Hcl; 4-(2-Chloroethyl)morpholine hydrochloride
  • SMILES ClCCN1CCOCC1.[H]Cl

Description

4-(2-Chloroethyl)morpholine hydrochloride is a bench-stable, moisture-tolerant electrophile featuring a reactive chloroethyl chain that facilitates efficient alkylation reactions. This compound integrates readily into synthetic workflows requiring site-specific functionalization, particularly in the construction of bioactive molecules and polymer architectures.

Application

4-(2-Chloroethyl)morpholine hydrochloride serves as a versatile bifunctional building block in medicinal chemistry, enabling efficient synthesis of morpholine-containing scaffolds. The chloroethyl group facilitates alkylation reactions under mild conditions, while the protonated morpholine nitrogen enhances solubility and reactivity in aqueous or polar media. This compound demonstrates excellent bench stability, ease of handling, and compatibility with standard purification protocols, making it ideal for constructing targeted heterocyclic frameworks in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS06
Signal Word : Danger
UN#: 2923
Class : 8 (6.1)
Packing Group : Ⅲ
Hazard Statements : H301-H312-H314-H317-H412
Precautionary Statements : P260-P261-P264-P270-P272-P273-P280-P301+P330+P331-P302+P352-P304+P340-P330-P362+P364-P363-P405-P501

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Computational Chemistry Data

  • TPSA   12.47
  • LogP   0.9792
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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